Effects of cannabidiol in males and females in two different rat models of depression

Liat Shbiro; Danielle Hen-Shoval; Noa Hazut; Kayla Rapps; Shira Dar; Gil Zalsman; Raphael Mechoulam; Aron Weller; Gal Shoval

doi:https://doi.org/10.1016/j.physbeh.2018.12.019

Effects of cannabidiol in males and females in two different rat models of depression

Liat Shbiro, Danielle Hen-Shoval, Noa Hazut, Kayla Rapps, Shira Dar, Gil Zalsman, Raphael Mechoulam, Aron Weller, Gal Shoval

Tel Aviv University, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Physiology and Behavior
Volume	201
DOIs	https://doi.org/10.1016/j.physbeh.2018.12.019
State	Published - 15 Mar 2019

Keywords

Animal models of depression
Cannabidiol
Depression
Flinders Sensitive Line
Wistar- Kyoto rats

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Behavioral Neuroscience

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https://doi.org/10.1016/j.physbeh.2018.12.019

Cite this

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title = "Effects of cannabidiol in males and females in two different rat models of depression",

abstract = "The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.",

keywords = "Animal models of depression, Cannabidiol, Depression, Flinders Sensitive Line, Wistar- Kyoto rats",

author = "Liat Shbiro and Danielle Hen-Shoval and Noa Hazut and Kayla Rapps and Shira Dar and Gil Zalsman and Raphael Mechoulam and Aron Weller and Gal Shoval",

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T1 - Effects of cannabidiol in males and females in two different rat models of depression

AU - Shbiro, Liat

AU - Hen-Shoval, Danielle

AU - Hazut, Noa

AU - Rapps, Kayla

AU - Dar, Shira

AU - Zalsman, Gil

AU - Mechoulam, Raphael

AU - Weller, Aron

AU - Shoval, Gal

PY - 2019/3/15

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N2 - The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.

AB - The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.

KW - Animal models of depression

KW - Cannabidiol

KW - Depression

KW - Flinders Sensitive Line

KW - Wistar- Kyoto rats

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M3 - مقالة

C2 - 30571957

SN - 0031-9384

VL - 201

SP - 59

EP - 63

JO - Physiology and Behavior

JF - Physiology and Behavior

ER -

Effects of cannabidiol in males and females in two different rat models of depression

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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