TY - JOUR
T1 - Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs
T2 - A randomized, double-blind pilot trial
AU - Stout, Jeffrey R.
AU - Smith-Ryan, Abbie E.
AU - Fukuda, David H.
AU - Kendall, Kristina L.
AU - Moon, Jordan R.
AU - Hoffman, Jay R.
AU - Wilson, Jacob M.
AU - Oliver, Jeffery S.
AU - Mustad, Vikkie A.
N1 - Funding Information: The research was supported by a grant from Abbott Nutrition, Columbus, OH . Study design, planning and statistical analysis were done in conjunction with Abbott Nutrition. All authors had full access to study data. The corresponding author and principal investigator, J.R. Stout has the final responsibility for the decision to submit the publication.
PY - 2013/11
Y1 - 2013/11
N2 - Background: Evidence suggests CaHMB may impact muscle mass and/or strength in older adults, yet no long-term studies have compared its effectiveness in sedentary and resistance training conditions. The purpose of this study was to evaluate the effects of 24weeks of CaHMB supplementation and resistance training (3dwk-1) or CaHMB supplementation only in ≥65yr old adults. Methods: This double-blinded, placebo-controlled, trial occurred in two phases under ad libitum conditions. Phase I consisted of two non-exercise groups: (a) placebo and (b) 3g CaHMB consumed twice daily. Phase II consisted of two resistance exercise groups: (a) placebo and resistance exercise and (b) 3g CaHMB consumed twice daily and resistance exercise (RE). Strength and functionality were assessed in both phases with isokinetic leg extension and flexion at 60°·s-1 and 180°·s-1 (LE60, LF60, LE180, LF180), hand grip strength (HG) and get-up-and-go (GUG). Dual X-Ray Absorptiometry (DXA) was used to measure arm, leg, and total body lean mass (LM) as well as total fat mass (FM). Muscle Quality was measured for arm (MQHG=HG/arm LM) and Leg (MQ60=LE60/leg LM) (MQ180=LE180/leg LM). Results: At 24weeks of Phase I, change in LE60 (+8.8%) and MQ180 (+20.8%) for CaHMB was significantly (p<0.05) greater than that for placebo group. Additionally, only CaHMB showed significant (p<0.05) improvements in total LM (2.2%), leg LM (2.1%), and LE180 (+17.3%), though no treatment effect was observed. Phase II demonstrated that RE significantly improved total LM (4.3%), LE60 (22.8%), LE180 (21.4%), HG (9.8%), and GUG (10.2%) with no difference between treatment groups. At week 24, only CaHMB group significantly improved FM (-3.8%) and MQHG (7.3%); however there was no treatment main effect for these variables. Conclusion: CaHMB improved strength and MQ without RE. Further, RE is an effective intervention for improving all measures of body composition and functionality.
AB - Background: Evidence suggests CaHMB may impact muscle mass and/or strength in older adults, yet no long-term studies have compared its effectiveness in sedentary and resistance training conditions. The purpose of this study was to evaluate the effects of 24weeks of CaHMB supplementation and resistance training (3dwk-1) or CaHMB supplementation only in ≥65yr old adults. Methods: This double-blinded, placebo-controlled, trial occurred in two phases under ad libitum conditions. Phase I consisted of two non-exercise groups: (a) placebo and (b) 3g CaHMB consumed twice daily. Phase II consisted of two resistance exercise groups: (a) placebo and resistance exercise and (b) 3g CaHMB consumed twice daily and resistance exercise (RE). Strength and functionality were assessed in both phases with isokinetic leg extension and flexion at 60°·s-1 and 180°·s-1 (LE60, LF60, LE180, LF180), hand grip strength (HG) and get-up-and-go (GUG). Dual X-Ray Absorptiometry (DXA) was used to measure arm, leg, and total body lean mass (LM) as well as total fat mass (FM). Muscle Quality was measured for arm (MQHG=HG/arm LM) and Leg (MQ60=LE60/leg LM) (MQ180=LE180/leg LM). Results: At 24weeks of Phase I, change in LE60 (+8.8%) and MQ180 (+20.8%) for CaHMB was significantly (p<0.05) greater than that for placebo group. Additionally, only CaHMB showed significant (p<0.05) improvements in total LM (2.2%), leg LM (2.1%), and LE180 (+17.3%), though no treatment effect was observed. Phase II demonstrated that RE significantly improved total LM (4.3%), LE60 (22.8%), LE180 (21.4%), HG (9.8%), and GUG (10.2%) with no difference between treatment groups. At week 24, only CaHMB group significantly improved FM (-3.8%) and MQHG (7.3%); however there was no treatment main effect for these variables. Conclusion: CaHMB improved strength and MQ without RE. Further, RE is an effective intervention for improving all measures of body composition and functionality.
KW - Exercise
KW - Fat mass
KW - Muscle quality
KW - Sarcopenia
KW - β-Hydroxy-β-methylbutyrate
UR - http://www.scopus.com/inward/record.url?scp=84884369507&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.exger.2013.08.007
DO - https://doi.org/10.1016/j.exger.2013.08.007
M3 - مقالة
C2 - 23981904
SN - 0531-5565
VL - 48
SP - 1303
EP - 1310
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 11
ER -