Editorial: Developmental Biology and Regulation of Osteoclasts

First Paragraph:
The proper structure and function of the skeleton is critical for the health and well-being of vertebrates. Bone structures enable growth, posture, movement, protect the internal organs, regulate calcium levels, and provide the proper environment for production and maturation of several types of hematopoietic cells. Bone is reshaped and renewed throughout life by the processes of bone modeling and remodeling, respectively (Sims and Vrahnas, 2014). These processes depend on the coordinated actions of mesenchymal-derived osteoblasts, which form new bone matrix, and hematopoietic-derived osteoclasts, which remove it (Sims and Vrahnas, 2014). Osteocytes, which are osteoblast lineage cells that reside within the bone matrix, and regulate the opposing activities of osteoblasts and osteoclasts in response to physiological and pathological cues (Schaffler et al., 2014).