Early post-liver transplant thrombocytopenia in children: Clinical characteristics and significance

Orith Waisbourd-Zinman, Eytan Kaplan, Gili Kadmon, Yulia Gendler, Michael Gurevich, Avichai Weissbach

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Post-liver transplant thrombocytopenia is common and associated with worse outcome in adults. In children, however, the prevalence, course, and significance of post-liver transplantation thrombocytopenia are not described. Therefore, we aimed to assess this phenomenon in children. Methods: A retrospective chart review of children who underwent liver transplantation at a single tertiary center between 2004 and 2021. Results: Overall, 130 pediatric liver transplantations were reviewed. During the first 28 POD, thrombocytopenia was evident in 116 (89%, 95% CI 83%–94%). The median nadir platelet count was 54 K/μl (IQR: 37–99). Nadir platelet count was reached in half the patients by the third POD (IQR: 1–6). In multivariate analysis, preoperative platelet count (p =.024), volume of intraoperative packed cell transfusion (p =.045), and hypersplenism (p =.007) were associated with lower postoperative platelet counts. Patients with platelet count lower than the 50th centile on the first POD suffered from a more complicated course leading to a longer PICU admission (p =.039). Conclusions: Early post-liver transplant thrombocytopenia appears to be common in children and associated with preoperative thrombocytopenia, hypersplenism, and higher intraoperative blood transfusion volumes. A low first POD platelet count (<86 K/μl) was found to be independently associated with a more complicated postoperative course, suggesting the need for heightened surveillance.

Original languageEnglish
Article numbere14326
JournalPediatric Transplantation
Volume26
Issue number6
DOIs
StatePublished - Sep 2022

Keywords

  • blood transfusion
  • hypersplenism
  • liver transplantation
  • pediatric intensive care unit
  • thrombocytopenia

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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