Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons

Eran Perlson; Adam G. Hendricks; Jacob E. Lazarus; Keren Ben-Yaakov; Tal Gradus; Mariko Tokito; Erika L.F. Holzbaur

doi:10.1074/jbc.M113.465088

Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons

Eran Perlson, Adam G. Hendricks, Jacob E. Lazarus, Keren Ben-Yaakov, Tal Gradus, Mariko Tokito, Erika L.F. Holzbaur

Physiology Pharmacology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Dynein is a microtubule motor that can also tether dynamic microtubule plus-ends. Results: Neural cell adhesion molecule isoform-180 (NCAM180) binds directly to dynein, facilitating microtubule tethering at the cortex and enhancing cell-cell adhesion and synaptic density. Conclusion: The dynein-NCAM180 interaction contributes to the maintenance of synaptic density in cortical neurons. Significance: Dynein functions as both microtubule motor and microtubule tether in neurons.

Original language	English
Pages (from-to)	27812-27824
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M113.465088
State	Published - 27 Sep 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.465088

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title = "Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons",

abstract = "Background: Dynein is a microtubule motor that can also tether dynamic microtubule plus-ends. Results: Neural cell adhesion molecule isoform-180 (NCAM180) binds directly to dynein, facilitating microtubule tethering at the cortex and enhancing cell-cell adhesion and synaptic density. Conclusion: The dynein-NCAM180 interaction contributes to the maintenance of synaptic density in cortical neurons. Significance: Dynein functions as both microtubule motor and microtubule tether in neurons.",

author = "Eran Perlson and Hendricks, \{Adam G.\} and Lazarus, \{Jacob E.\} and Keren Ben-Yaakov and Tal Gradus and Mariko Tokito and Holzbaur, \{Erika L.F.\}",

year = "2013",

month = sep,

day = "27",

doi = "10.1074/jbc.M113.465088",

language = "الإنجليزيّة",

volume = "288",

pages = "27812--27824",

journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons

AU - Perlson, Eran

AU - Hendricks, Adam G.

AU - Lazarus, Jacob E.

AU - Ben-Yaakov, Keren

AU - Gradus, Tal

AU - Tokito, Mariko

AU - Holzbaur, Erika L.F.

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: Dynein is a microtubule motor that can also tether dynamic microtubule plus-ends. Results: Neural cell adhesion molecule isoform-180 (NCAM180) binds directly to dynein, facilitating microtubule tethering at the cortex and enhancing cell-cell adhesion and synaptic density. Conclusion: The dynein-NCAM180 interaction contributes to the maintenance of synaptic density in cortical neurons. Significance: Dynein functions as both microtubule motor and microtubule tether in neurons.

AB - Background: Dynein is a microtubule motor that can also tether dynamic microtubule plus-ends. Results: Neural cell adhesion molecule isoform-180 (NCAM180) binds directly to dynein, facilitating microtubule tethering at the cortex and enhancing cell-cell adhesion and synaptic density. Conclusion: The dynein-NCAM180 interaction contributes to the maintenance of synaptic density in cortical neurons. Significance: Dynein functions as both microtubule motor and microtubule tether in neurons.

UR - http://www.scopus.com/inward/record.url?scp=84884771377&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.465088

DO - 10.1074/jbc.M113.465088

M3 - مقالة

SN - 0021-9258

VL - 288

SP - 27812

EP - 27824

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

ER -

Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons

Abstract

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