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Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors
Hiruy S. Meharena
,
Asaf Marco
, Vishnu Dileep
, Elana R. Lockshin
, Grace Y. Akatsu
, James Mullahoo
, L. Ashley Watson
, Tak Ko
, Lindsey N. Guerin
, Fatema Abdurrob
, Shruthi Rengarajan
, Malvina Papanastasiou
, Jacob D. Jaffe
, Li Huei Tsai
Research output
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Article
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peer-review
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Keyphrases
Down Syndrome
100%
Chromosome 21
100%
Nuclear Architecture
100%
Neural Progenitors
100%
Triplication
100%
Induced Senescence
100%
Induced Pluripotent Stem Cells (iPSCs)
33%
Cellular Dysfunction
16%
Tissue Sampling
16%
Genetic Disease
16%
Neurodevelopment
16%
Stem Cell-derived
16%
Neurodevelopmental Disabilities
16%
Transcriptome
16%
Extraversion
16%
Transcriptome Analysis
16%
Change Characteristics
16%
Physical Disability
16%
Associated Phenotypes
16%
Senescence-associated
16%
Senolytics
16%
Accessibility Change
16%
Lamina-associated Domain
16%
Transcriptional Architecture
16%
Biochemistry, Genetics and Molecular Biology
Down Syndrome
100%
Chromosome 21
100%
Progenitor Cell
33%
Gene Expression Profiling
16%
Transcriptome
16%
Human Induced Pluripotent Stem Cell
16%
Genetic Disorder
16%
Induced Pluripotent Stem Cell
16%
Chromatin Accessibility
16%
Introversion
16%