TY - JOUR
T1 - Dopaminergic medication reduces interhemispheric hyper-synchronization in Parkinson's disease
AU - Koren, Or
AU - Bartsch, Ronny P.
AU - Katzir, Zoya
AU - Rosenblum, Uri
AU - Hassin-Baer, Sharon
AU - Inzelberg, Rivka
AU - Plotnik, Meir
N1 - Publisher Copyright: © 2022 Elsevier Ltd
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Introduction: We previously reported on interhemispheric cortical hyper synchronization in PD. The aim of the present study was to address the hypothesis that increased interhemispheric cortical synchronization in PD is related to dopamine deficiency and is correlated with motor function. Methods: We studied participants with PD and characterized cortical synchronization with reference to brain regions. Electroencephalography (EEG) was recorded from 20 participants with PD while OFF and ON their dopaminergic medications (two separate visits), during quiet standing and straight-line walking. Cortical interactions in the theta, alpha, beta, and gamma brain wave frequency bands were evaluated using interhemispheric phase synchronization (inter-PS). Results: Inter-PS values were found to be significantly higher during the OFF state as compared to the ON state in standing and walking trials for theta, alpha and beta bands. In addition, inter-PS reduction from OFF to ON was associated with mobility improvement evaluated by the Timed Up and Go test, and with daily levodopa equivalent dose across individuals. Higher differences in inter-PS values between OFF and ON states were evident mainly in the occipital-parietal cortex. Conclusions: Persons with PD have increased inter-PS during the OFF state compared to their ON state, and this increase in inter-PS is associated with the clinical improvement between OFF and ON. We speculate that these findings, together with previous evidence of higher inter-PS in PD as compared to healthy older adults, reflect neuronal processes consequential to asymmetric subcortical dopamine deficiency.
AB - Introduction: We previously reported on interhemispheric cortical hyper synchronization in PD. The aim of the present study was to address the hypothesis that increased interhemispheric cortical synchronization in PD is related to dopamine deficiency and is correlated with motor function. Methods: We studied participants with PD and characterized cortical synchronization with reference to brain regions. Electroencephalography (EEG) was recorded from 20 participants with PD while OFF and ON their dopaminergic medications (two separate visits), during quiet standing and straight-line walking. Cortical interactions in the theta, alpha, beta, and gamma brain wave frequency bands were evaluated using interhemispheric phase synchronization (inter-PS). Results: Inter-PS values were found to be significantly higher during the OFF state as compared to the ON state in standing and walking trials for theta, alpha and beta bands. In addition, inter-PS reduction from OFF to ON was associated with mobility improvement evaluated by the Timed Up and Go test, and with daily levodopa equivalent dose across individuals. Higher differences in inter-PS values between OFF and ON states were evident mainly in the occipital-parietal cortex. Conclusions: Persons with PD have increased inter-PS during the OFF state compared to their ON state, and this increase in inter-PS is associated with the clinical improvement between OFF and ON. We speculate that these findings, together with previous evidence of higher inter-PS in PD as compared to healthy older adults, reflect neuronal processes consequential to asymmetric subcortical dopamine deficiency.
KW - Electroencephalography
KW - Parkinson's disease
KW - Phase synchronization
UR - http://www.scopus.com/inward/record.url?scp=85126282925&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.parkreldis.2022.02.009
DO - https://doi.org/10.1016/j.parkreldis.2022.02.009
M3 - مقالة
C2 - 35299069
SN - 1353-8020
VL - 97
SP - 39
EP - 46
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -