Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn2+ in the HP92 loop of ribosomal RNA

Ilia Kaminker; Morgan Bye; Natanel Mendelman; Kristmann Gislason; Snorri Th Sigurdsson; Daniella Goldfarb

doi:10.1039/c5cp01624j

Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn²⁺ in the HP92 loop of ribosomal RNA

Ilia Kaminker, Morgan Bye, Natanel Mendelman, Kristmann Gislason, Snorri Th Sigurdsson, Daniella Goldfarb

Department of Chemical and Biological Physics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Mn²⁺ localization in hairpin 92 of the 23S ribosomal RNA (HP92) was obtained using W-band (95 GHz) DEER (double electron-electron resonance) distance measurements between the Mn²⁺ ion and nitroxide spin labels on the RNA. It was found to be preferably situated in the minor groove of the double strand region close to the HP92 loop.

Original language	English
Pages (from-to)	15098-15102
Number of pages	5
Journal	Physical Chemistry Chemical Physics
Volume	17
Issue number	23
DOIs	https://doi.org/10.1039/c5cp01624j
State	Published - 21 Jun 2015

All Science Journal Classification (ASJC) codes

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1039/c5cp01624j

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title = "Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn2+ in the HP92 loop of ribosomal RNA",

abstract = "Mn2+ localization in hairpin 92 of the 23S ribosomal RNA (HP92) was obtained using W-band (95 GHz) DEER (double electron-electron resonance) distance measurements between the Mn2+ ion and nitroxide spin labels on the RNA. It was found to be preferably situated in the minor groove of the double strand region close to the HP92 loop.",

author = "Ilia Kaminker and Morgan Bye and Natanel Mendelman and Kristmann Gislason and Sigurdsson, \{Snorri Th\} and Daniella Goldfarb",

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year = "2015",

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doi = "10.1039/c5cp01624j",

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T1 - Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn2+ in the HP92 loop of ribosomal RNA

AU - Kaminker, Ilia

AU - Bye, Morgan

AU - Mendelman, Natanel

AU - Gislason, Kristmann

AU - Sigurdsson, Snorri Th

AU - Goldfarb, Daniella

PY - 2015/6/21

Y1 - 2015/6/21

N2 - Mn2+ localization in hairpin 92 of the 23S ribosomal RNA (HP92) was obtained using W-band (95 GHz) DEER (double electron-electron resonance) distance measurements between the Mn2+ ion and nitroxide spin labels on the RNA. It was found to be preferably situated in the minor groove of the double strand region close to the HP92 loop.

AB - Mn2+ localization in hairpin 92 of the 23S ribosomal RNA (HP92) was obtained using W-band (95 GHz) DEER (double electron-electron resonance) distance measurements between the Mn2+ ion and nitroxide spin labels on the RNA. It was found to be preferably situated in the minor groove of the double strand region close to the HP92 loop.

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U2 - 10.1039/c5cp01624j

DO - 10.1039/c5cp01624j

M3 - مقالة

C2 - 25994415

SN - 1463-9076

VL - 17

SP - 15098

EP - 15102

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 23

ER -

Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn²⁺ in the HP92 loop of ribosomal RNA

Abstract

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