Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit

Uğur Çetiner, Oren Raz, Madolyn Britt, Sergei Sukharev

Research output: Contribution to journalArticlepeer-review

Abstract

The Landauer principle sets a thermodynamic bound of kBT ln 2 on the energetic cost of erasing each bit of information. It holds for any memory device, regardless of its physical implementation. It was recently shown that carefully built artificial devices can attain this bound. In contrast, biological computation-like processes, e.g., DNA replication, transcription and translation use an order of magnitude more than their Landauer minimum. Here, we show that reaching the Landauer bound is nevertheless possible with biological devices. This is achieved using a mechanosensitive channel of small conductance (MscS) from E. coli as a memory bit. MscS is a fast-acting osmolyte release valve adjusting turgor pressure inside the cell. Our patch-clamp experiments and data analysis demonstrate that under a slow switching regime, the heat dissipation in the course of tension-driven gating transitions in MscS closely approaches its Landauer limit. We discuss the biological implications of this physical trait.

Original languageEnglish
Article number779
JournalEntropy
Volume25
Issue number5
DOIs
StatePublished - May 2023

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Electrical and Electronic Engineering
  • General Physics and Astronomy
  • Mathematical Physics
  • Physics and Astronomy (miscellaneous)

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