Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

Nabeel S. Ganem; Noa Ben-Asher; Aidan C. Manning; Sarah N. Deffit; Michael C. Washburn; Emily C. Wheeler; Gene W. Yeo; Orna Ben Naim Zgayer; Einav Mantsur; Heather A. Hundley; Ayelet T. Lamm

doi:10.1016/j.celrep.2019.03.095

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

Nabeel S. Ganem, Noa Ben-Asher, Aidan C. Manning, Sarah N. Deffit, Michael C. Washburn, Emily C. Wheeler, Gene W. Yeo, Orna Ben Naim Zgayer, Einav Mantsur, Heather A. Hundley, Ayelet T. Lamm

Biology

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.

Original language	English
Pages (from-to)	1244-1253.e4
Journal	Cell Reports
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2019.03.095
State	Published - 23 Apr 2019

Keywords

ADAR
C. elegans
gene expression
organism development
transcriptomics

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2019.03.095

Cite this

@article{1103ad789ba54db6a3edfc2cfe5f6714,

title = "Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing",

abstract = "Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.",

keywords = "ADAR, C. elegans, gene expression, organism development, transcriptomics",

author = "Ganem, \{Nabeel S.\} and Noa Ben-Asher and Manning, \{Aidan C.\} and Deffit, \{Sarah N.\} and Washburn, \{Michael C.\} and Wheeler, \{Emily C.\} and Yeo, \{Gene W.\} and Zgayer, \{Orna Ben Naim\} and Einav Mantsur and Hundley, \{Heather A.\} and Lamm, \{Ayelet T.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = apr,

day = "23",

doi = "10.1016/j.celrep.2019.03.095",

language = "الإنجليزيّة",

volume = "27",

pages = "1244--1253.e4",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

AU - Ganem, Nabeel S.

AU - Ben-Asher, Noa

AU - Manning, Aidan C.

AU - Deffit, Sarah N.

AU - Washburn, Michael C.

AU - Wheeler, Emily C.

AU - Yeo, Gene W.

AU - Zgayer, Orna Ben Naim

AU - Mantsur, Einav

AU - Hundley, Heather A.

AU - Lamm, Ayelet T.

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.

AB - Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.

KW - ADAR

KW - C. elegans

KW - gene expression

KW - organism development

KW - transcriptomics

UR - http://www.scopus.com/inward/record.url?scp=85064174222&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.03.095

DO - 10.1016/j.celrep.2019.03.095

M3 - مقالة

C2 - 31018137

SN - 2211-1247

VL - 27

SP - 1244-1253.e4

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this