Discrete-time competing-risks regression with or without penalization

Tomer Meir, Malka Gorfine

Research output: Contribution to journalArticlepeer-review

Abstract

Many studies employ the analysis of time-to-event data that incorporates competing risks and right censoring. Most methods and software packages are geared towards analyzing data that comes from a continuous failure time distribution. However, failure-time data may sometimes be discrete either because time is inherently discrete or due to imprecise measurement. This paper introduces a new estimation procedure for discrete-time survival analysis with competing events. The proposed approach offers a major key advantage over existing procedures and allows for straightforward integration and application of widely used regularized regression and screening-features methods. We illustrate the benefits of our proposed approach by a comprehensive simulation study. Additionally, we showcase the utility of the proposed procedure by estimating a survival model for the length of stay of patients hospitalized in the intensive care unit, considering 3 competing events: discharge to home, transfer to another medical facility, and in-hospital death. A Python package, PyDTS, is available for applying the proposed method with additional features.

Original languageEnglish
Article numberujaf040
JournalBiometrics
Volume81
Issue number2
DOIs
StatePublished - 2 Apr 2025

Keywords

  • competing events
  • penalized regression
  • regularized regression
  • sure independent screening
  • survival analysis

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics

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