Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

Andrea Bonetti; Sara Pellegrino; Priyadip Das; Sivan Yuran; Raffaella Bucci; Nicola Ferri; Fiorella Meneghetti; Carlo Castellano; Meital Reches; Maria Luisa Gelmi

doi:https://doi.org/10.1021/acs.orglett.5b02132

Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β^2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

Andrea Bonetti, Sara Pellegrino, Priyadip Das, Sivan Yuran, Raffaella Bucci, Nicola Ferri, Fiorella Meneghetti, Carlo Castellano, Meital Reches, Maria Luisa Gelmi

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β^2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

Original language	English
Pages (from-to)	4468-4471
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.5b02132
State	Published - 18 Sep 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications",

abstract = "The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.",

author = "Andrea Bonetti and Sara Pellegrino and Priyadip Das and Sivan Yuran and Raffaella Bucci and Nicola Ferri and Fiorella Meneghetti and Carlo Castellano and Meital Reches and Gelmi, {Maria Luisa}",

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doi = "https://doi.org/10.1021/acs.orglett.5b02132",

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T1 - Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

AU - Bonetti, Andrea

AU - Pellegrino, Sara

AU - Das, Priyadip

AU - Yuran, Sivan

AU - Bucci, Raffaella

AU - Ferri, Nicola

AU - Meneghetti, Fiorella

AU - Castellano, Carlo

AU - Reches, Meital

AU - Gelmi, Maria Luisa

PY - 2015/9/18

Y1 - 2015/9/18

N2 - The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

AB - The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

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U2 - https://doi.org/10.1021/acs.orglett.5b02132

DO - https://doi.org/10.1021/acs.orglett.5b02132

M3 - مقالة

C2 - 26335611

SN - 1523-7060

VL - 17

SP - 4468

EP - 4471

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β^2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

Abstract

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