Differentiation of pluripotent stem cells to skeletal muscle for cultivated meat applications

Michelle Hauser, Iftach Nachman, Gaya Savyon

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In this chapter, we provide an overview of the various strategies for differentiating pluripotent stem cells into skeletal muscle, the main tissue type in meat. We discuss the challenges and opportunities regarding efficiency and costs they arise in the different parameters of cultivated meat production bioprocess: 2D versus 3D cultivation and directed differentiation versus direct reprogramming differentiation methods. We examine the various factors that need to be considered when selecting a particular differentiation strategy for cultivated meat production.

Original languageEnglish
Title of host publicationCellular Agriculture
Subtitle of host publicationTechnology, Society, Sustainability and Science
Number of pages12
ISBN (Electronic)9780443187674
ISBN (Print)9780443187667
StatePublished - 1 Jan 2023


  • Cultivated meat bioprocess
  • Differentiation
  • Myogenesis
  • Pluripotent stem cells
  • Skeletal muscle
  • Skeletal muscle organoid

All Science Journal Classification (ASJC) codes

  • General Social Sciences


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