Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity

Anat Shemer, Steffen Jung

Research output: Contribution to journalReview articlepeer-review


Macrophages can be of dual origin. Most tissue-resident macrophage compartments are generated before birth and subsequently maintain themselves independently from each other locally in healthy tissue. Under inflammatory conditions, these cells can however be complemented by macrophages derived from acute monocyte infiltrates. Due to the lack of suitable experimental systems, differential functional contributions of central nervous system (CNS)-resident microglia and monocyte-derived macrophages (MoMF) to CNS inflammation, such as experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis (MS), remain poorly understood. Here, we will review recent progress in this field that suggest distinct roles of microglia and MoMF in disease induction and progression, capitalizing on novel transgenic mouse models. The latter finding could have major implications for the rationale development of therapeutic approaches to the management of brain inflammation and MS therapy.

Original languageEnglish
Pages (from-to)613-623
Number of pages11
JournalSeminars in Immunopathology
Issue number6
StatePublished - 1 Nov 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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