Diastereodivergent combined carbometalation/zinc homologation/C-C fragmentation reaction as an efficient tool to prepare acyclic allylic quaternary carbon stereocenters

Sudipta Raha Roy; Dorian Didier; Amir Kleiner; Ilan Marek

doi:10.1039/c6sc02191c

Diastereodivergent combined carbometalation/zinc homologation/C-C fragmentation reaction as an efficient tool to prepare acyclic allylic quaternary carbon stereocenters

Sudipta Raha Roy, Dorian Didier, Amir Kleiner, Ilan Marek

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A new strategy has been developed to construct enantiomerically enriched acyclic allylic quaternary carbon stereocenters in a single-pot operation through a combined carbometalation/zinc homologation/fragmentation sequence. Proper tuning of the reaction conditions enables the synthesis of the two enantiomers starting from a single enantiomer of the starting material.

Original language	English
Pages (from-to)	5989-5994
Number of pages	6
Journal	Chemical Science
Volume	7
Issue number	9
DOIs	https://doi.org/10.1039/c6sc02191c
State	Published - 2016

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1039/c6sc02191c

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title = "Diastereodivergent combined carbometalation/zinc homologation/C-C fragmentation reaction as an efficient tool to prepare acyclic allylic quaternary carbon stereocenters",

abstract = "A new strategy has been developed to construct enantiomerically enriched acyclic allylic quaternary carbon stereocenters in a single-pot operation through a combined carbometalation/zinc homologation/fragmentation sequence. Proper tuning of the reaction conditions enables the synthesis of the two enantiomers starting from a single enantiomer of the starting material.",

author = "Roy, \{Sudipta Raha\} and Dorian Didier and Amir Kleiner and Ilan Marek",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6sc02191c",

language = "الإنجليزيّة",

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AU - Roy, Sudipta Raha

AU - Didier, Dorian

AU - Kleiner, Amir

AU - Marek, Ilan

PY - 2016

Y1 - 2016

N2 - A new strategy has been developed to construct enantiomerically enriched acyclic allylic quaternary carbon stereocenters in a single-pot operation through a combined carbometalation/zinc homologation/fragmentation sequence. Proper tuning of the reaction conditions enables the synthesis of the two enantiomers starting from a single enantiomer of the starting material.

AB - A new strategy has been developed to construct enantiomerically enriched acyclic allylic quaternary carbon stereocenters in a single-pot operation through a combined carbometalation/zinc homologation/fragmentation sequence. Proper tuning of the reaction conditions enables the synthesis of the two enantiomers starting from a single enantiomer of the starting material.

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U2 - 10.1039/c6sc02191c

DO - 10.1039/c6sc02191c

M3 - مقالة

SN - 2041-6520

VL - 7

SP - 5989

EP - 5994

JO - Chemical Science

JF - Chemical Science

IS - 9

ER -

Diastereodivergent combined carbometalation/zinc homologation/C-C fragmentation reaction as an efficient tool to prepare acyclic allylic quaternary carbon stereocenters

Abstract

All Science Journal Classification (ASJC) codes

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