Diagnosis Efficacy of Cone-Beam Computed Tomography in Endodontics—A Systematic Review of High-Level-Evidence Studies

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Introduction: The integration of clinical inspection and diagnostic imaging forms the basis for endodontic diagnosis, decision making, treatment planning, and outcome assessments. In recent years, CBCT imaging has become a common diagnostic tool in endodontics. CBCT should only be used to ensure that the benefits to the patient exceed the risks. As such, our aim in this study was to evaluate the high level diagnostic efficacy studies and their risk of bias. Methods: A systematic search of the literature was conducted to identify studies evaluating the use of CBCT imaging in endodontics. The following databases were searched: Medline (PubMed), Scopus, and Cochrane Central. The identified studies were subjected to rigorous inclusion criteria. Studies considered as having a high efficacy level were then subjected to a risk of bias assessment using the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. Results: Initially, 1568 articles were identified for possible inclusion in the review. Following title and abstract assessment, duplicate removal, and a full-text evaluation, 22 studies were included. Of those studies, 2 had a low risk of bias and 20 had a high risk of bias. Six studies investigated non-surgical treatment, eight investigated surgical treatment, two investigated both non-surgical and surgical treatment, and six studies investigated diagnostic thinking or decision making. Conclusion: The evidence for the influence of CBCT on decision making and treatment outcomes in endodontics is predominantly based on studies with a high risk of bias.

Original languageEnglish
Article number938
JournalApplied Sciences (Switzerland)
Issue number3
StatePublished - 1 Feb 2022


  • Cone-beam computed tomography
  • Diagnosis efficacy
  • Endodontics
  • Systematic review

All Science Journal Classification (ASJC) codes

  • General Engineering
  • Instrumentation
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • General Materials Science
  • Computer Science Applications


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