@inproceedings{a8861bda6c974ba998859aced068eb15,
title = "Development of local surface plasmon resonance sensor using gold nanoparticles",
abstract = "The healthcare industry is moving towards personalized medicine and patients seek greater role in their care. In this paper we describe a proof of concept of versatile optical sensor that potentially can be used for in vivo detection of biological events. The developed sensor comprises of a silver thin film glass slide and gold nanoparticles (GNPs) and allows detection of chemical changes using surface plasmon resonance (SPR), local surface plasmon resonance (LSPR) and fluorescence lifetime detection modalities. A change in spectrum was observed after removal of GNPs by 2-mercaptoethanol. Moreover, GNP conjugated to fluorescein were tested using fluorescence lifetime microscopy (FLIM) to enhance sensing capabilities and provide additional dimension for detection. The sensor has the potential to provide real-time analyses of different biological molecules, such as antibody and antigen, receptor and ligand, and complementary DNA fragments.",
keywords = "Fluorescence lifetime imaging, Gold nanoparticles, Local Surface Plasmon Resonance (LSPR)",
author = "Marianna Beiderman and Menachem Motiei and Rachela Popovtzer and Dror Fixler",
note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019 ; Conference date: 03-02-2019 Through 04-02-2019",
year = "2019",
doi = "10.1117/12.2509667",
language = "الإنجليزيّة",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Goldys, {Ewa M.} and Dror Fixler and Nicolau, {Dan V.}",
booktitle = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI",
address = "الولايات المتّحدة",
}