Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour; Alina Kordonsky; Yevgeny Berdichevsky; Gali Prag; Avraham Ashkenazi

doi:10.1038/s41419-020-03361-5

Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour
, Alina Kordonsky
, Yevgeny Berdichevsky
, Gali Prag
, Avraham Ashkenazi

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]

Original language	English
Article number	120
Journal	Cell Death and Disease
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41419-020-03361-5
State	Published - 1 Jan 2021

ASJC Scopus subject areas

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

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10.1038/s41419-020-03361-5

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AU - Prag, Gali

AU - Ashkenazi, Avraham

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AB - Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]

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DO - 10.1038/s41419-020-03361-5

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Deubiquitylating enzymes in neuronal health and disease

Abstract

ASJC Scopus subject areas

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