Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour; Alina Kordonsky; Yevgeny Berdichevsky; Gali Prag; Avraham Ashkenazi

doi:10.1038/s41419-020-03361-5

Deubiquitylating enzymes in neuronal health and disease

Fatima Amer-Sarsour, Alina Kordonsky, Yevgeny Berdichevsky, Gali Prag, Avraham Ashkenazi

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. [Figure not available: see fulltext.]

Original language	English
Article number	120
Journal	Cell Death and Disease
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41419-020-03361-5
State	Published - 1 Jan 2021

All Science Journal Classification (ASJC) codes

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41419-020-03361-5

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AU - Ashkenazi, Avraham

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Deubiquitylating enzymes in neuronal health and disease

Abstract

All Science Journal Classification (ASJC) codes

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