Detection and analysis of conservation at synonymous sites

Nimrod D. Rubinstein; Tal Pupko

doi:https://doi.org/10.1093/acprof:osobl/9780199601165.003.0014

Detection and analysis of conservation at synonymous sites

Nimrod D. Rubinstein, Tal Pupko

Department of Cell Research and Immunology

Tel Aviv University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter describes several causes of codon usage bias, namely translational selection, mRNA structure, overlapping genes, and splicing signals. It provides an overview of the implications of these factors specifically to the detection and analysis of conservation at synonymous sites. It discusses various codon-based evolutionary models that have recently been developed and their application to the detection of conserved synonymous sites.

Original language	English
Title of host publication	Codon Evolution
Subtitle of host publication	Mechanisms and Models
Publisher	Oxford University Press
ISBN (Electronic)	9780191810114
ISBN (Print)	9780199601165
DOIs	https://doi.org/10.1093/acprof:osobl/9780199601165.003.0014
State	Published - 23 Feb 2012

Keywords

Codon models
Codon usage bias
Conservation
Overlapping genes
Splicing signals
Synonymous sites
Translational selection
mRNA structure

All Science Journal Classification (ASJC) codes

General Agricultural and Biological Sciences

Access to Document

https://doi.org/10.1093/acprof:osobl/9780199601165.003.0014

Cite this

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KW - Conservation

KW - Overlapping genes

KW - Splicing signals

KW - Synonymous sites

KW - Translational selection

KW - mRNA structure

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Detection and analysis of conservation at synonymous sites

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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