Abstract
Effective encapsulation and protection of biotherapeutics using a bio-based carrier, preferably issued from renewable resources, remains a challenge. Herein, we demonstrate application of coaxial electrospinning to fabric starch-based core-sheath compound fibers as a bacterial cells’ carrier. Starch-formate is employed as an encapsulation agent, while the fiber core is made of glycerol, serving as a cell suspension medium. SEM microscopy reveals a distinct core-sheath morphology of the starch-formate/glycerol (SFG) compound fibers with mean diameters of 4.13 ± 1.05 μm. Calorimetric and thermomechanical analyses and FTIR spectroscopy show a progressive interaction between the starch-formate and the glycerol with time, pronounced with temperature increase. SFG fibers with encapsulated Lactobacillus paracasei are proved stable with retained bacterial viability when stored at 4 °C and room temperature for up to 21 days. SFG fibers present a potential biotherapeutic products’ encapsulation platform, guaranteeing the stability at refrigerated and ambient storage conditions, as determined in this study.
| Original language | English |
|---|---|
| Pages (from-to) | 68-76 |
| Number of pages | 9 |
| Journal | Carbohydrate Polymers |
| Volume | 158 |
| DOIs | |
| State | Published - 20 Feb 2017 |
Keywords
- Drug delivery systems
- Electrospun fibers
- Microencapsulation
- Starch
- Structure-property relations
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry
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