Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Ido M. Herzog; Mark Feldman; Anat Eldar-Boock; Ronit Satchi-Fainaro; Micha Fridman

doi:10.1039/c2md20162c

Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Ido M. Herzog, Mark Feldman, Anat Eldar-Boock, Ronit Satchi-Fainaro, Micha Fridman

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.

Original language	English
Pages (from-to)	120-124
Number of pages	5
Journal	MedChemComm
Volume	4
Issue number	1
DOIs	https://doi.org/10.1039/c2md20162c
State	Published - Jan 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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10.1039/c2md20162c

Cite this

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title = "Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity",

abstract = "Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.",

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AU - Fridman, Micha

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AB - Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.

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Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Abstract

All Science Journal Classification (ASJC) codes

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