TY - JOUR
T1 - Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study
T2 - A multicenter cohort observational study
AU - Corsonello, Andrea
AU - Tap, Lisanne
AU - Roller-Wirnsberger, Regina
AU - Wirnsberger, Gerhard
AU - Zoccali, Carmine
AU - Kostka, Tomasz
AU - Guligowska, Agnieszka
AU - Mattace-Raso, Francesco
AU - Gil, Pedro
AU - Fuentes, Lara Guardado
AU - Meltzer, Itshak
AU - Yehoshua, Ilan
AU - Formiga-Perez, Francesc
AU - Moreno-González, Rafael
AU - Weingart, Christian
AU - Freiberger, Ellen
AU - Ärnlöv, Johan
AU - Carlsson, Axel C.
AU - Bustacchini, Silvia
AU - Lattanzio, Fabrizia
AU - Bolognini, Silvia
AU - D'Ascoli, Paola
AU - Moresi, Raffaella
AU - Di Stefano, Giuseppina
AU - Cassetta, Laura
AU - Bonfigli, Anna Rita
AU - Galeazzi, Roberta
AU - Lenci, Federica
AU - Bella, Stefano Della
AU - Bordoni, Enrico
AU - Provinciali, Mauro
AU - Giacconi, Robertina
AU - Giuli, Cinzia
AU - Postacchini, Demetrio
AU - Garasto, Sabrina
AU - Firmani, Annalisa Cozza Romano
AU - Nacciariti, Moreno
AU - Di Rosa, Mirko
AU - Bernabei, Paolo Fabbietti Roberto
AU - Bula, Christophe
AU - Haller, Hermann
AU - Jager, Kitty
AU - Van Biesen, Wim
AU - Stevens, Paul E.
AU - Melzer, I
N1 - Publisher Copyright: © 2018 The Author(s).
PY - 2018/10/11
Y1 - 2018/10/11
N2 - Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months- follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people. Trial registration: This study was registered prospectively on the 25th February 2016 at clinicaltrials.gov (NCT02691546).
AB - Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months- follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people. Trial registration: This study was registered prospectively on the 25th February 2016 at clinicaltrials.gov (NCT02691546).
KW - Ageing
KW - Chronic kidney disease
KW - Disability
KW - Frailty
KW - Older people
UR - http://www.scopus.com/inward/record.url?scp=85054747216&partnerID=8YFLogxK
U2 - 10.1186/s12882-018-1030-2
DO - 10.1186/s12882-018-1030-2
M3 - مقالة
C2 - 30309342
SN - 1471-2369
VL - 19
JO - BMC Nephrology
JF - BMC Nephrology
IS - 1
M1 - 260
ER -
