TY - JOUR
T1 - Design, analysis and additive manufacturing of porous structures for biocompatible micro-scale scaffolds
AU - Podshivalov, Lev
AU - Gomes, Cynthia M.
AU - Zocca, Andrea
AU - Guenster, Jens
AU - Bar-Yoseph, Pinhas
AU - Fischer, Anath
N1 - Funding Information: Dr. Gomes and Dr. Podshivalov would like to thank the Minerva Foundation for financial support that led to this research. The authors also would like to acknowledge Dr. Staude (BAM) for providing the μCT measurements. This study was partially supported by the Samuel and Anne Tolkowsky Chair at the Technion.
PY - 2013
Y1 - 2013
N2 - Advancements in the fields of biocompatible materials, manufacturing processes, computational methods and medicine have led to the emergence of a new field: micro-scale scaffolds for bone replacement and regeneration. Yet most such scaffolds produced today are characterized by very basic geometry, and their microstructure differs greatly from that of the actual tissue they are intended to replace. In this paper, we propose a novel approach for generating micro-scale scaffolds based on processing actual micro-CT images and then reconstructing a highly accurate geometrical model. This model is manufactured by means of a state-of-the-art 3D additive manufacturing process from biocompatible materials. At the micro-scale level, these scaffolds are very similar to the original tissue, thus interfacing better with the surrounding tissue and facilitating more efficient rehabilitation for the patient. Moreover, the approach facilitates the design and manufacture of patient-specific scaffolds which can copy patients' exact structural and mechanical characteristics, taking into account their physical condition and medical history. By means of multi-resolution volumetric modeling methods, scaffold porosity can also be adapted according to specific mechanical requirements. The process of designing and manufacturing micro-scale scaffolds involves five major stages: (a) building a volumetric multi-resolution model from micro-CT images; (b) generation of surface geometric model in STL format; (c) additive manufacturing of the scaffold; (d) scaffold shape verification relative to the geometric design; and (e) verification of mechanical properties through finite element analysis. In this research, all the proposed stages of the approach were tested. The input included micro-CT scans of porous ceramic structure, which is quite similar to commercial porous scaffolds. The results show that the proposed method is feasible for design and manufacture of micro-scale scaffolds.
AB - Advancements in the fields of biocompatible materials, manufacturing processes, computational methods and medicine have led to the emergence of a new field: micro-scale scaffolds for bone replacement and regeneration. Yet most such scaffolds produced today are characterized by very basic geometry, and their microstructure differs greatly from that of the actual tissue they are intended to replace. In this paper, we propose a novel approach for generating micro-scale scaffolds based on processing actual micro-CT images and then reconstructing a highly accurate geometrical model. This model is manufactured by means of a state-of-the-art 3D additive manufacturing process from biocompatible materials. At the micro-scale level, these scaffolds are very similar to the original tissue, thus interfacing better with the surrounding tissue and facilitating more efficient rehabilitation for the patient. Moreover, the approach facilitates the design and manufacture of patient-specific scaffolds which can copy patients' exact structural and mechanical characteristics, taking into account their physical condition and medical history. By means of multi-resolution volumetric modeling methods, scaffold porosity can also be adapted according to specific mechanical requirements. The process of designing and manufacturing micro-scale scaffolds involves five major stages: (a) building a volumetric multi-resolution model from micro-CT images; (b) generation of surface geometric model in STL format; (c) additive manufacturing of the scaffold; (d) scaffold shape verification relative to the geometric design; and (e) verification of mechanical properties through finite element analysis. In this research, all the proposed stages of the approach were tested. The input included micro-CT scans of porous ceramic structure, which is quite similar to commercial porous scaffolds. The results show that the proposed method is feasible for design and manufacture of micro-scale scaffolds.
KW - Additive manufacturing
KW - Ceramics
KW - Micro-scale bone scaffolds
KW - Multiresolution modeling
KW - Multiscale FEA
UR - http://www.scopus.com/inward/record.url?scp=84883855700&partnerID=8YFLogxK
U2 - 10.1016/j.procir.2013.01.049
DO - 10.1016/j.procir.2013.01.049
M3 - مقالة من مؤنمر
SN - 2212-8271
VL - 5
SP - 247
EP - 252
JO - Procedia CIRP
JF - Procedia CIRP
T2 - 1st CIRP Conference on BioManufacturing, BioM 2013
Y2 - 3 March 2013 through 5 March 2013
ER -
