Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Lee Goren Zur; Ashgan Bishara; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman

doi:10.3390/md11114487

Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Lee Goren Zur
, Ashgan Bishara
, Maurice Aknin
, Drorit Neumann
, Nathalie Ben-Califa
, Yoel Kashman

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

Original language	English
Pages (from-to)	4487-4509
Number of pages	23
Journal	Marine Drugs
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/md11114487
State	Published - Nov 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Fascaplysinopsis sp.
Leukemia cells
Nitrogenous macrolide
Salarins
Sponge
Tulearins

ASJC Scopus subject areas

Drug Discovery

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10.3390/md11114487

Cite this

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title = "Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites",

abstract = "Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.",

keywords = "Fascaplysinopsis sp., Leukemia cells, Nitrogenous macrolide, Salarins, Sponge, Tulearins",

author = "Zur, \{Lee Goren\} and Ashgan Bishara and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman",

year = "2013",

month = nov,

doi = "10.3390/md11114487",

language = "الإنجليزيّة",

volume = "11",

pages = "4487--4509",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

AU - Zur, Lee Goren

AU - Bishara, Ashgan

AU - Aknin, Maurice

AU - Neumann, Drorit

AU - Ben-Califa, Nathalie

AU - Kashman, Yoel

PY - 2013/11

Y1 - 2013/11

N2 - Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

AB - Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

KW - Fascaplysinopsis sp.

KW - Leukemia cells

KW - Nitrogenous macrolide

KW - Salarins

KW - Sponge

KW - Tulearins

UR - https://www.scopus.com/pages/publications/84889238053

U2 - 10.3390/md11114487

DO - 10.3390/md11114487

M3 - مقالة

SN - 1660-3397

VL - 11

SP - 4487

EP - 4509

JO - Marine Drugs

JF - Marine Drugs

IS - 11

ER -

Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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