Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Lee Goren Zur; Ashgan Bishara; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman

doi:https://doi.org/10.3390/md11114487

Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Lee Goren Zur, Ashgan Bishara, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

Original language	English
Pages (from-to)	4487-4509
Number of pages	23
Journal	Marine Drugs
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/md11114487
State	Published - Nov 2013

Keywords

Fascaplysinopsis sp.
Leukemia cells
Nitrogenous macrolide
Salarins
Sponge
Tulearins

All Science Journal Classification (ASJC) codes

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.3390/md11114487

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title = "Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites",

abstract = "Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.",

keywords = "Fascaplysinopsis sp., Leukemia cells, Nitrogenous macrolide, Salarins, Sponge, Tulearins",

author = "Zur, {Lee Goren} and Ashgan Bishara and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman",

year = "2013",

month = nov,

doi = "https://doi.org/10.3390/md11114487",

language = "الإنجليزيّة",

volume = "11",

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journal = "Marine Drugs",

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TY - JOUR

T1 - Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

AU - Zur, Lee Goren

AU - Bishara, Ashgan

AU - Aknin, Maurice

AU - Neumann, Drorit

AU - Ben-Califa, Nathalie

AU - Kashman, Yoel

PY - 2013/11

Y1 - 2013/11

N2 - Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

AB - Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

KW - Fascaplysinopsis sp.

KW - Leukemia cells

KW - Nitrogenous macrolide

KW - Salarins

KW - Sponge

KW - Tulearins

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U2 - https://doi.org/10.3390/md11114487

DO - https://doi.org/10.3390/md11114487

M3 - مقالة

SN - 1660-3397

VL - 11

SP - 4487

EP - 4509

JO - Marine Drugs

JF - Marine Drugs

IS - 11

ER -

Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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