Abstract
A strategy for the synthesis of dehydroalanine based diubiquitin activity probes is described. The site-specific introduction of dehydroalanine was achieved from diubiquitin bearing Cys residue near the scissile bond between two ubiquitins linked through Lys48, Lys63 or in a head to tail fashion. The probes were characterized for their activities with various deubiquitinases, which open new opportunities in studying deubiquitinases in various settings.
Original language | American English |
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Pages (from-to) | 540-543 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - 17 Jan 2014 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry