Dehydroalanine-based diubiquitin activity probes

Najat Haj-Yahya, Hosahalli P. Hemantha, Roman Meledin, Somasekhar Bondalapati, Mallikanti Seenaiah, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

Abstract

A strategy for the synthesis of dehydroalanine based diubiquitin activity probes is described. The site-specific introduction of dehydroalanine was achieved from diubiquitin bearing Cys residue near the scissile bond between two ubiquitins linked through Lys48, Lys63 or in a head to tail fashion. The probes were characterized for their activities with various deubiquitinases, which open new opportunities in studying deubiquitinases in various settings.

Original languageAmerican English
Pages (from-to)540-543
Number of pages4
JournalOrganic Letters
Volume16
Issue number2
DOIs
StatePublished - 17 Jan 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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