@article{b315ff3f3a9d40a986dffbb81cecdbf8,
title = "Defining Human Pluripotency",
abstract = "Human pluripotent stem cells harbor the capacity to differentiate into cells from the three embryonic germ layers, and this ability grants them a central role in modeling human disorders and in the field of regenerative medicine. Here, we review pluripotency in human cells with respect to four different aspects: (1) embryonic development, (2) transcriptomes of pluripotent cell stages, (3) genes and pathways that reprogram somatic cells into pluripotent stem cells, and finally (4) the recent identification of the human pluripotent stem cell essentialome. These four aspects of pluripotency collectively culminate in a broader understanding of what makes a cell pluripotent.",
author = "Atilgan Yilmaz and Nissim Benvenisty",
note = "Funding Information: We thank members of the Azrieli Center for Stem Cells and Genetic Research at the Hebrew University of Jerusalem for their input and critical reading of the manuscript. We thank Motti Peretz and Shiran Bar for their assistance with data analyses. This work was partially supported by the US-Israel Binational Science Foundation (grant no. 2015089 ), by the Israel Science Foundation (grant no. 494/17 ), and by the Azrieli Foundation . A.Y. is supported by a Lady Davis Postdoctoral Fellowship and N.B. is the Herbert Cohn Chair in Cancer Research. Funding Information: We thank members of the Azrieli Center for Stem Cells and Genetic Research at the Hebrew University of Jerusalem for their input and critical reading of the manuscript. We thank Motti Peretz and Shiran Bar for their assistance with data analyses. This work was partially supported by the US-Israel Binational Science Foundation (grant no. 2015089), by the Israel Science Foundation (grant no. 494/17), and by the Azrieli Foundation. A.Y. is supported by a Lady Davis Postdoctoral Fellowship and N.B. is the Herbert Cohn Chair in Cancer Research. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jul,
day = "3",
doi = "https://doi.org/10.1016/j.stem.2019.06.010",
language = "English",
volume = "25",
pages = "9--22",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "1",
}
