Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome

Yumi Minyi Yao, Irina Miodownik, Michael P. O’Hagan, Muhammad Jbara, Ariel Afek

Research output: Contribution to journalReview articlepeer-review

Abstract

Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs. These interactions occur within a dynamic cellular environment, where both DNA and TF proteins experience continual chemical and structural perturbations, including epigenetic modifications, DNA damage, mechanical stress, and post-translational modifications (PTMs). While many of these factors impact TF-DNA binding interactions, understanding their effects remains challenging and incomplete. This review explores the existing literature on these dynamic changes and their potential impact on TF-DNA interactions.

Original languageAmerican English
JournalTranscription
Early online date20 Jul 2024
DOIs
StatePublished Online - 20 Jul 2024

Keywords

  • DNA
  • DNA damage
  • DNA mechanics
  • epigenetic modification
  • protein-DNA interaction
  • repair enzyme
  • transcription factor

All Science Journal Classification (ASJC) codes

  • Genetics
  • Biochemistry
  • Biotechnology

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