De Novo Phospholipid Synthesis Promotes Efficient Autophagy

Autophagy is an intracellular membrane trafficking process responsible for recycling of macromolecules and organelles and overall cell survival under physiological and pathophysiological conditions.1 It is mediated by a distinct set of core autophagic factors termed ATGs together with general intracellular trafficking factors such as SNAREs, tethering complexes, etc. This adaptive process of formation of a de novo double-membrane organelle is induced under different metabolic and stress conditions, including nutrient deprivation, growth factor depletion, infection, and hypoxia. [first paragraph]