DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

Galina M. Proshkina; Elena I. Shramova; Marya V. Shilova; Ivan V. Zelepukin; Victoria O. Shipunova; Anastasia V. Ryabova; Sergey M. Deyev; Alexander B. Kotlyar

doi:10.3390/cancers13205235

DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

Galina M. Proshkina, Elena I. Shramova, Marya V. Shilova, Ivan V. Zelepukin, Victoria O. Shipunova, Anastasia V. Ryabova, Sergey M. Deyev, Alexander B. Kotlyar

Biochemistry Molecular Biology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

Original language	English
Article number	5235
Journal	Cancers
Volume	13
Issue number	20
DOIs	https://doi.org/10.3390/cancers13205235
State	Published - 1 Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
DARPin
Gold nanorods
Mice treatment
Near-infrared illumination
Photothermal therapy

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.3390/cancers13205235

Cite this

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title = "DARPin\_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice",

abstract = "Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin\_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.",

keywords = "Cancer, DARPin, Gold nanorods, Mice treatment, Near-infrared illumination, Photothermal therapy",

author = "Proshkina, \{Galina M.\} and Shramova, \{Elena I.\} and Shilova, \{Marya V.\} and Zelepukin, \{Ivan V.\} and Shipunova, \{Victoria O.\} and Ryabova, \{Anastasia V.\} and Deyev, \{Sergey M.\} and Kotlyar, \{Alexander B.\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = oct,

day = "1",

doi = "10.3390/cancers13205235",

language = "الإنجليزيّة",

volume = "13",

journal = "Cancers",

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T1 - DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

AU - Proshkina, Galina M.

AU - Shramova, Elena I.

AU - Shilova, Marya V.

AU - Zelepukin, Ivan V.

AU - Shipunova, Victoria O.

AU - Ryabova, Anastasia V.

AU - Deyev, Sergey M.

AU - Kotlyar, Alexander B.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

AB - Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

KW - Cancer

KW - DARPin

KW - Gold nanorods

KW - Mice treatment

KW - Near-infrared illumination

KW - Photothermal therapy

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U2 - 10.3390/cancers13205235

DO - 10.3390/cancers13205235

M3 - مقالة

C2 - 34680384

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 20

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ER -

DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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