TY - JOUR
T1 - Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance
AU - Golan, Karin
AU - Kumari, Anju
AU - Kollet, Orit
AU - Khatib-Massalha, Eman
AU - Subramaniam, Mohana Devi
AU - Ferreira, Zulma S.
AU - Avemaria, Francesca
AU - Rzeszotek, Sylwia
AU - Garcia-Garcia, Andres
AU - Xie, Stephanie
AU - Flores-Figueroa, Eugenia
AU - Gur-Cohen, Shiri
AU - Itkin, Tomer
AU - Ludin-Tal, Aya
AU - Massalha, Hassan
AU - Bernshtein, Biana
AU - Ciechanowicz, Andrzej K.
AU - Brandis, Alexander
AU - Mehlman, Tevie
AU - Bhattacharya, Suditi
AU - Bertagna, Mayla
AU - Cheng, Hui
AU - Petrovich-Kopitman, Ekaterina
AU - Janus, Tomasz
AU - Kaushansky, Nathali
AU - Cheng, Tao
AU - Sagi, Irit
AU - Ratajczak, Mariusz Z.
AU - Mendez-Ferrer, Simon
AU - Dick, John E.
AU - Markus, Regina P.
AU - Lapidot, Tsvee
PY - 2018/10/4
Y1 - 2018/10/4
N2 - Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Light-induced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/αSMA + macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation. Golan et al. report that daily onsets of light and dark induce NE and TNF bursts that induce two different peaks of BM HSPC activity. Light-induced NE promotes HSPC differentiation and egress, replenishing mature blood cells. Dark-induced TNF promotes melatonin-dependent renewal of CD150 + HSCs and their long-term repopulation potential.
AB - Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Light-induced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/αSMA + macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation. Golan et al. report that daily onsets of light and dark induce NE and TNF bursts that induce two different peaks of BM HSPC activity. Light-induced NE promotes HSPC differentiation and egress, replenishing mature blood cells. Dark-induced TNF promotes melatonin-dependent renewal of CD150 + HSCs and their long-term repopulation potential.
U2 - https://doi.org/10.1016/j.stem.2018.08.002
DO - https://doi.org/10.1016/j.stem.2018.08.002
M3 - مقالة
C2 - 30174297
SN - 1934-5909
VL - 23
SP - 572
EP - 585
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 4
ER -