TY - JOUR
T1 - D-Serine
T2 - Physiology and pathology
AU - Radzishevsky, Inna
AU - Sason, Hagit
AU - Wolosker, Herman
PY - 2013/1
Y1 - 2013/1
N2 - PURPOSE OF REVIEW: Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity. RECENT FINDINGS: D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms. Recent data indicate that like glial D-serine, neuronal D-serine is required for NMDAR-dependent, long-term potentiation at the hippocampal CA1-CA3 synapses and proper synapse formation in the cerebral cortex. D-serine is the physiological coagonist of synaptic NMDAR, whereas glycine action is restricted to extrasynaptic sites. SUMMARY: D-Serine is now recognized as the major NMDAR coagonist at the synapse. The data establish D-serine as a key transmitter or neuromodulator that mediates synaptic NMDAR activation and neurotoxicity. In this context, drugs that inhibit D-serine synthesis or release will provide new neuroprotective strategy.
AB - PURPOSE OF REVIEW: Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity. RECENT FINDINGS: D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms. Recent data indicate that like glial D-serine, neuronal D-serine is required for NMDAR-dependent, long-term potentiation at the hippocampal CA1-CA3 synapses and proper synapse formation in the cerebral cortex. D-serine is the physiological coagonist of synaptic NMDAR, whereas glycine action is restricted to extrasynaptic sites. SUMMARY: D-Serine is now recognized as the major NMDAR coagonist at the synapse. The data establish D-serine as a key transmitter or neuromodulator that mediates synaptic NMDAR activation and neurotoxicity. In this context, drugs that inhibit D-serine synthesis or release will provide new neuroprotective strategy.
KW - D-serine
KW - NMDA receptors
KW - gliotransmission
UR - http://www.scopus.com/inward/record.url?scp=84871922837&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=technion_pure2wos&SrcAuth=WosAPI&KeyUT=WOS:000312065300012&DestLinkType=FullRecord&DestApp=WOS
U2 - https://doi.org/10.1097/MCO.0b013e32835a3466
DO - https://doi.org/10.1097/MCO.0b013e32835a3466
M3 - مقالة مرجعية
C2 - 23041616
SN - 1363-1950
VL - 16
SP - 72
EP - 75
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
IS - 1
ER -