D-Serine: Physiology and pathology

Inna Radzishevsky, Hagit Sason, Herman Wolosker

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity. RECENT FINDINGS: D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms. Recent data indicate that like glial D-serine, neuronal D-serine is required for NMDAR-dependent, long-term potentiation at the hippocampal CA1-CA3 synapses and proper synapse formation in the cerebral cortex. D-serine is the physiological coagonist of synaptic NMDAR, whereas glycine action is restricted to extrasynaptic sites. SUMMARY: D-Serine is now recognized as the major NMDAR coagonist at the synapse. The data establish D-serine as a key transmitter or neuromodulator that mediates synaptic NMDAR activation and neurotoxicity. In this context, drugs that inhibit D-serine synthesis or release will provide new neuroprotective strategy.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number1
StatePublished - Jan 2013


  • D-serine
  • NMDA receptors
  • gliotransmission

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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