Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Hagai Glasner; Edit Y. Tshuva

doi:10.1016/j.inoche.2015.01.019

Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Hagai Glasner, Edit Y. Tshuva

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)₄ and analyzed by ¹H, ¹³C and diffusion NMR. The comparative hydrolytic stability in 1:9 D₂O/DMSO-d₆ was assessed by ¹H NMR, and the complexes featured t_1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC₅₀ value of 77 ± 40 μM.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	53
DOIs	https://doi.org/10.1016/j.inoche.2015.01.019
State	Published - May 2015

Keywords

Cisplatin
Cytotoxicity
Metallodrugs
Phenolato ligands
Titanium(IV)

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.inoche.2015.01.019

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title = "Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands",

abstract = "Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.",

keywords = "Cisplatin, Cytotoxicity, Metallodrugs, Phenolato ligands, Titanium(IV)",

author = "Hagai Glasner and Tshuva, \{Edit Y.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = may,

doi = "10.1016/j.inoche.2015.01.019",

language = "الإنجليزيّة",

volume = "53",

pages = "31--33",

journal = "Inorganic Chemistry Communications",

issn = "1387-7003",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

AU - Glasner, Hagai

AU - Tshuva, Edit Y.

PY - 2015/5

Y1 - 2015/5

N2 - Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.

AB - Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.

KW - Cisplatin

KW - Cytotoxicity

KW - Metallodrugs

KW - Phenolato ligands

KW - Titanium(IV)

UR - http://www.scopus.com/inward/record.url?scp=84920998718&partnerID=8YFLogxK

U2 - 10.1016/j.inoche.2015.01.019

DO - 10.1016/j.inoche.2015.01.019

M3 - مقالة

SN - 1387-7003

VL - 53

SP - 31

EP - 33

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

ER -

Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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