Abstract
Adaptive immunity depends on the production and maintenance of a pool of mature peripheral lymphocytes throughout life. The signals regulating the survival of mature splenic B cells have become a major focus in recent studies of B cell immunology. Lasting B cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. Cytokines have been shown to play a critical role in maintaining lymphocyte homeostasis. This review focuses on the role of cytokines and their receptors in the regulation of peripheral B cell survival, with an emphasis on those that have received relatively less attention in the literature.
Original language | English |
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Pages (from-to) | 13-22 |
Number of pages | 10 |
Journal | Cytokine |
Volume | 60 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2012 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Hematology
- Biochemistry
- Immunology and Allergy
- Immunology