Cytokines as regulators of proliferation and survival of healthy and malignant peripheral B cells

Sivan Cohen, Idit Shachar

Research output: Contribution to journalReview articlepeer-review

Abstract

Adaptive immunity depends on the production and maintenance of a pool of mature peripheral lymphocytes throughout life. The signals regulating the survival of mature splenic B cells have become a major focus in recent studies of B cell immunology. Lasting B cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. Cytokines have been shown to play a critical role in maintaining lymphocyte homeostasis. This review focuses on the role of cytokines and their receptors in the regulation of peripheral B cell survival, with an emphasis on those that have received relatively less attention in the literature.

Original languageEnglish
Pages (from-to)13-22
Number of pages10
JournalCytokine
Volume60
Issue number1
DOIs
StatePublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Biochemistry
  • Immunology and Allergy
  • Immunology

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