TY - JOUR
T1 - Cyclopentane FIT-PNAs
T2 - Bright RNA sensors
AU - Tepper, Odelia
AU - Zheng, Hongchao
AU - Appella, Daniel H.
AU - Yavin, Eylon
N1 - Funding Information: This research was supported by THE ISRAEL SCIENCE FOUNDATION (grant no. 476/17). EY acknowledges the David R. Bloom Center for Pharmacy and the Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics for financial support. The authors are grateful to Prof. Gonen Ashkenasy for help with Tm measurements. Publisher Copyright: © 2021 The Royal Society of Chemistry.
PY - 2021/1/14
Y1 - 2021/1/14
N2 - Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
AB - Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
UR - http://www.scopus.com/inward/record.url?scp=85099559632&partnerID=8YFLogxK
U2 - https://doi.org/10.1039/d0cc07400d
DO - https://doi.org/10.1039/d0cc07400d
M3 - Article
C2 - 33336664
SN - 1359-7345
VL - 57
SP - 540
EP - 543
JO - Chemical Communications
JF - Chemical Communications
IS - 4
ER -