Cut Your Losses: Spastin Mediates Branch-Specific Axon Loss

Hagar Meltzer; Oren Schuldiner

doi:10.1016/j.neuron.2016.11.004

Cut Your Losses: Spastin Mediates Branch-Specific Axon Loss

Hagar Meltzer, Oren Schuldiner

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

In this issue of Neuron, Brill et al. (2016) demonstrate that, during synapse elimination in the developing neuromuscular junction, branch-specific microtubule destabilization results in arrested axonal transport and induces axon branch loss. This process is mediated in part by the neurodegeneration-associated, microtubule-severing protein spastin.

Original language	English
Pages (from-to)	677-680
Number of pages	4
Journal	Neuron
Volume	92
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2016.11.004
State	Published - 23 Nov 2016

All Science Journal Classification (ASJC) codes

General Neuroscience

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title = "Cut Your Losses: Spastin Mediates Branch-Specific Axon Loss",

abstract = "In this issue of Neuron, Brill et al. (2016) demonstrate that, during synapse elimination in the developing neuromuscular junction, branch-specific microtubule destabilization results in arrested axonal transport and induces axon branch loss. This process is mediated in part by the neurodegeneration-associated, microtubule-severing protein spastin.",

author = "Hagar Meltzer and Oren Schuldiner",

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AB - In this issue of Neuron, Brill et al. (2016) demonstrate that, during synapse elimination in the developing neuromuscular junction, branch-specific microtubule destabilization results in arrested axonal transport and induces axon branch loss. This process is mediated in part by the neurodegeneration-associated, microtubule-severing protein spastin.

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Cut Your Losses: Spastin Mediates Branch-Specific Axon Loss

Abstract

All Science Journal Classification (ASJC) codes

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