Crystalline calcium carbonate and hydrogels as microenvironment for stem cells

Liliana Astachov; Zvi Nevo; Moran Aviv; Razi Vago

doi:10.2741/3698

Crystalline calcium carbonate and hydrogels as microenvironment for stem cells

Liliana Astachov, Zvi Nevo, Moran Aviv, Razi Vago

Tel Aviv University, Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell - based on embryonic and adult stem cells as potent, cellular sources - for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.

Original language	English
Pages (from-to)	458-471
Number of pages	14
Journal	Frontiers in Bioscience - Landmark
Volume	16
Issue number	2
DOIs	https://doi.org/10.2741/3698
State	Published - 1 Jan 2011

Keywords

Aragonite
Calcite
Hyaluronan
Hydrogel
MSCs
Review

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
General Biochemistry,Genetics and Molecular Biology

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10.2741/3698

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AB - Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell - based on embryonic and adult stem cells as potent, cellular sources - for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.

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KW - Hydrogel

KW - MSCs

KW - Review

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JF - Frontiers in Bioscience - Landmark

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Crystalline calcium carbonate and hydrogels as microenvironment for stem cells

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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