Abstract
The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .
Original language | English |
---|---|
Pages (from-to) | 1871-1876 |
Number of pages | 6 |
Journal | Russian Chemical Bulletin |
Volume | 62 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- Crystal packing
- Drug formulation
- Hydrogen bonding
- Hydrogen peroxide
- Peroxosolvates
- Pyridinemonocarboxylic acids
- X-ray dif- fraction
All Science Journal Classification (ASJC) codes
- General Chemistry