Crystal structures of pyridinemonocarboxylic acid peroxosolvates

A. G. Medvedev, A. A. Mikhailov, P. V. Prikhodchenko, T. A. Tripol’skaya, O. Lev, A. V. Churakov

Research output: Contribution to journalArticlepeer-review

Abstract

The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .

Original languageEnglish
Pages (from-to)1871-1876
Number of pages6
JournalRussian Chemical Bulletin
Volume62
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Crystal packing
  • Drug formulation
  • Hydrogen bonding
  • Hydrogen peroxide
  • Peroxosolvates
  • Pyridinemonocarboxylic acids
  • X-ray dif- fraction

All Science Journal Classification (ASJC) codes

  • General Chemistry

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