Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39

Research output: Contribution to journalReview articlepeer-review


Zinc is essential for many physiological functions, with a major role in digestive system, skin health, and learning and memory. On the cellular level, zinc is involved in cell proliferation and cell death. A selective zinc sensing receptor, ZnR/GPR39 is a Gq-coupled receptor that acts via the inositol trisphosphate pathway to release intracellular Ca2+. The ZnR/GPR39 serves as a mediator between extracellular changes in Zn2+ concentration and cellular Ca2+ signalling. This signalling pathway regulates ion transporters activity and thereby controls the formation of transepithelial gradients or neuronal membrane potential, which play a fundamental role in the physiological function of these tissues. This review focuses on the role of Ca2+ signalling, and specifically ZnR/GPR39, with respect to the regulation of the Na+/H+ exchanger, NHE1, and of the K+/Cl cotransporters, KCC1-3, and also describes the physiological implications of this regulation. (Figure presented.).

Original languageAmerican English
Pages (from-to)1579-1594
Number of pages16
JournalJournal of Physiology
Issue number8
StatePublished - 15 Apr 2024


  • KCC1
  • KCC2
  • KCC3
  • NHE1
  • ZnR/GPR39
  • calcium signalling
  • zinc signalling

All Science Journal Classification (ASJC) codes

  • Physiology


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