Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Suresh Kumar Poovathingal; Nataly Kravchenko-Balasha; Young Shik Shin; Raphael David Levine; James R. Heath

doi:10.1002/smll.201501178

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Suresh Kumar Poovathingal, Nataly Kravchenko-Balasha, Young Shik Shin, Raphael David Levine, James R. Heath

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

Original language	English
Pages (from-to)	1425-1431
Number of pages	7
Journal	Small
Volume	12
Issue number	11
DOIs	https://doi.org/10.1002/smll.201501178
State	Published - 16 Mar 2016

Keywords

carcinogenesis
microfluidics
phase transition
single-cell proteomics
steady state

All Science Journal Classification (ASJC) codes

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

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10.1002/smll.201501178

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title = "Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics",

abstract = "A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.",

keywords = "carcinogenesis, microfluidics, phase transition, single-cell proteomics, steady state",

author = "Poovathingal, \{Suresh Kumar\} and Nataly Kravchenko-Balasha and Shin, \{Young Shik\} and Levine, \{Raphael David\} and Heath, \{James R.\}",

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year = "2016",

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doi = "10.1002/smll.201501178",

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T2 - A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

AU - Poovathingal, Suresh Kumar

AU - Kravchenko-Balasha, Nataly

AU - Shin, Young Shik

AU - Levine, Raphael David

AU - Heath, James R.

PY - 2016/3/16

Y1 - 2016/3/16

N2 - A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

AB - A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

KW - carcinogenesis

KW - microfluidics

KW - phase transition

KW - single-cell proteomics

KW - steady state

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U2 - 10.1002/smll.201501178

DO - 10.1002/smll.201501178

M3 - مقالة

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SN - 1613-6810

VL - 12

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EP - 1431

JO - Small

JF - Small

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ER -

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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