@inbook{0a6caaa5248c4a2c820cfae1f33d9ff2,
title = "Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch",
abstract = "Tissue engineering is an approach used to create a functional cardiac patch for the purpose of scar support after a myocardial infarct (MI). Cardiac cells, or cells of other sources, are seeded into scaffolds, which provide an artificial biomechanical support until the cells secrete extracellular matrix and regenerate into a functional tissue. In this chapter we describe the creative design of various cell microenvironments, which promote the development of a thick vascularized cardiac patch, ready to face the harsh conditions of the infarcted heart. Among these microenvironments are unique bioreactor systems that increase mass transfer through the developing cardiac tissue at the in vitro engineering stage and the use of various vascularization techniques, including the use of the body as a bioreactor to induce rapid vascularization prior to transplantation on the infarcted heart.",
keywords = "Cardiac Tissue, Infarcted Heart, Microvascular Network, Perfusion Bioreactor, Vascular Endothelial Growth Factor",
author = "Tal Dvir and Jonathan Leor and Smadar Cohen",
note = "Publisher Copyright: {\textcopyright} 2010, Springer-Verlag Berlin Heidelberg.",
year = "2011",
month = jan,
day = "1",
doi = "https://doi.org/10.1007/8415_2010_40",
language = "الإنجليزيّة",
series = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
pages = "81--94",
booktitle = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
}