Abstract
We studied the presence of Kaposi sarcoma herpesvirus sequences in cell-free DNA (cfDNA) isolated from the blood of patients with AIDS-related Kaposi sarcoma (KS) and primary effusion lymphoma (PEL). The use of paramagnetic beads linked to methyl-CpG binding domain protein allowed separation of virion and cell-derived DNA. Only virion DNA was detected in the blood of KS patients, whereas cell-derived DNA was detected in a patient with AIDS-related PEL. The difference in the origins of cfDNA in these settings may in part reflect very different proliferative indices in KS and PEL tumor tissue.
Original language | English |
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Pages (from-to) | 1095-1099 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 205 |
Issue number | 7 |
DOIs | |
State | Published - 1 Apr 2012 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Immunology and Allergy