TY - JOUR
T1 - CpG Islands as a putative source for animal miRNAs
T2 - Evolutionary and functional implications
AU - Dahary, Dvir
AU - Shalgi, Reut
AU - Pilpel, Yitzhak
N1 - European Commission (EC) [FP7, 201102]; Ben-May FoundationWe thank Moshe Oren and the Pilpel laboratory for stimulating discussions. Work in the authors' laboratories is supported by European Commission (EC) FP7 funding (ONCOMIRS, grant agreement number 201102). The EC is not liable for any use made of the information contained herein. We thank the Ben-May Foundation for continuous support.
PY - 2011/5
Y1 - 2011/5
N2 - MicroRNAs (miRs) are considered major contributors to the evolution of animal morphological complexity. Multiple bursts of novel miR families were documented throughout animal evolution, yet, their evolutionary origins are not understood. Here, we discuss two alternative genomic sources for novel miR families, namely, transposable elements, which were previously described, and a newly proposed origin: CpG islands. We show that these two origins are evolutionarily distinct and that they correspond to marked differences in several functional and genomic characteristics. Together, our results shed light on the intriguing origin of one of the major constituents of regulatory networks in animals, miRs.
AB - MicroRNAs (miRs) are considered major contributors to the evolution of animal morphological complexity. Multiple bursts of novel miR families were documented throughout animal evolution, yet, their evolutionary origins are not understood. Here, we discuss two alternative genomic sources for novel miR families, namely, transposable elements, which were previously described, and a newly proposed origin: CpG islands. We show that these two origins are evolutionarily distinct and that they correspond to marked differences in several functional and genomic characteristics. Together, our results shed light on the intriguing origin of one of the major constituents of regulatory networks in animals, miRs.
KW - CpG islands
KW - animal evolution
KW - microRNA
UR - http://www.scopus.com/inward/record.url?scp=79955413359&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/molbev/msq315
DO - https://doi.org/10.1093/molbev/msq315
M3 - مقالة
SN - 0737-4038
VL - 28
SP - 1545
EP - 1551
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 5
ER -