@article{c72cdc4dc6a24e40aa4457c61898cd52,
title = "Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli",
abstract = "Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide measurements demonstrate that genes with similar mRNA profiles often exhibit marked differences in the amplitude and onset of their production rate. The latter is characterized by a large dynamic range, with a group of genes exhibiting an unexpectedly strong transient production overshoot, thereby accelerating their induction and, when combined with time-dependent degradation, shaping transient responses with precise timing and amplitude.",
keywords = "half-life, operational strategy, pre-mRNA, transcriptional response",
author = "Amit Zeisel and K{\"o}stler, {Wolfgang J.} and Natali Molotski and Tsai, {Jonathan M.} and Rita Krauthgamer and Jasmine Jacob-Hirsch and Gideon Rechavi and Yoav Soen and Steffen Jung and Yosef Yarden and Eytan Domany",
note = "Leir Charitable Foundation; Weizmann-Mario Negri; MD Moross Institute for Cancer Research, Arresto Biosciences; European Commission; Dr Miriam and Sheldon Adelson Medical Research Foundation; Kekst Family Institute for Medical Genetics; Kirk Center for Childhood Cancer and Immunological Disorders; Bennett-Pritzker Endowment Fund; Marvelle Koffler Program for Breast Cancer Research; German Research Foundation (DIP); National Cancer Institute [CA72981]; Flight Attendants Medical Research Institute (FAMRI); Linda and Michael Jacobs Charitable TrustWe thank Naama Barkai, Uri Alon, Tzachi Pilpel and Moshe Oren for fruitful discussions. This work was supported by the Leir Charitable Foundation, a Weizmann-Mario Negri collaborative research grant, the MD Moross Institute for Cancer Research, Arresto Biosciences, the European Commission, the Dr Miriam and Sheldon Adelson Medical Research Foundation, the Kekst Family Institute for Medical Genetics, the Kirk Center for Childhood Cancer and Immunological Disorders, the Women's Health Research Center funded by the Bennett-Pritzker Endowment Fund, the Marvelle Koffler Program for Breast Cancer Research, the German Research Foundation (DIP), National Cancer Institute (CA72981), and the Flight Attendants Medical Research Institute (FAMRI). ED is the incumbent of the Henri J Leir Professorial Chair, YY is the incumbent of the Harold and Zelda Goldenberg Professorial Chair, GR holds the Djerassi Chair in Oncology at the Tel-Aviv University and WJK is supported by a PhD Track for Specialist MDs fellowship of The Linda and Michael Jacobs Charitable Trust.",
year = "2011",
month = sep,
day = "13",
doi = "https://doi.org/10.1038/msb.2011.62",
language = "الإنجليزيّة",
volume = "7",
journal = "Molecular Systems Biology",
issn = "1744-4292",
publisher = "Springer Science and Business Media Deutschland GmbH",
}