Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Peter Siman; Subramanian Vedhanarayanan Karthikeyan; Miroslav Nikolov; Wolfgang Fischle; Ashraf Brik

doi:10.1002/anie.201303844

Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Peter Siman, Subramanian Vedhanarayanan Karthikeyan, Miroslav Nikolov, Wolfgang Fischle, Ashraf Brik

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

Original language	American English
Pages (from-to)	8059-8063
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	31
DOIs	https://doi.org/10.1002/anie.201303844
State	Published - 29 Jul 2013

Keywords

H2B protein
chromatin
peptide ligation
proteins
ubiquitination

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201303844

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abstract = "As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.",

keywords = "H2B protein, chromatin, peptide ligation, proteins, ubiquitination",

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AU - Fischle, Wolfgang

AU - Brik, Ashraf

PY - 2013/7/29

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KW - chromatin

KW - peptide ligation

KW - proteins

KW - ubiquitination

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JO - Angewandte Chemie - International Edition

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Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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