Contributions of low and high spatial frequency processing to impaired object recognition circuitry in schizophrenia

Daniel J. Calderone, Matthew J. Hoptman, Antígona Martínez, Sangeeta Nair-Collins, Cristina J. Mauro, Moshe Bar, Daniel C. Javitt, Pamela D. Butler

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with schizophrenia exhibit cognitive and sensory impairment, and object recognition deficits have been linked to sensory deficits. The "frame and fill" model of object recognition posits that low spatial frequency (LSF) information rapidly reaches the prefrontal cortex (PFC) and creates a general shape of an object that feeds back to the ventral temporal cortex to assist object recognition. Visual dysfunction findings in schizophrenia suggest a preferential loss of LSF information. This study used functional magnetic resonance imaging (fMRI) and resting state functional connectivity (RSFC) to investigate the contribution of visual deficits to impaired object "framing" circuitry in schizophrenia. Participants were shown object stimuli that were intact or contained only LSF or high spatial frequency (HSF) information. For controls, fMRI revealed preferential activation to LSF information in precuneus, superior temporal, and medial and dorsolateral PFC areas, whereas patients showed a preference for HSF information or no preference. RSFC revealed a lack of connectivity between early visual areas and PFC for patients. These results demonstrate impaired processing of LSF information during object recognition in schizophrenia, with patients instead displaying increased processing of HSF information. This is consistent with findings of a preference for local over global visual information in schizophrenia.

Original languageEnglish
Pages (from-to)1849-1858
Number of pages10
JournalCerebral Cortex
Volume23
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • cortical circuitry
  • magnocellular
  • object recognition
  • schizophrenia
  • visual

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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