Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Julia Farache; Ehud Zigmond; Guy Shakhar; Steffen Jung

doi:https://doi.org/10.1038/icb.2012.79

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Julia Farache, Ehud Zigmond, Guy Shakhar, Steffen Jung

Tel Aviv University, Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103 + dendritic cells and CX3CR1 + macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).

Original language	English
Pages (from-to)	232-239
Number of pages	8
Journal	Immunology and Cell Biology
Volume	91
Issue number	3
DOIs	https://doi.org/10.1038/icb.2012.79
State	Published - Mar 2013

Keywords

dendritic cells
homeostasis
inflammation
intestine
macrophages

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Cell Biology
Immunology

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https://doi.org/10.1038/icb.2012.79

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title = "Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense",

abstract = "Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103 + dendritic cells and CX3CR1 + macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).",

keywords = "dendritic cells, homeostasis, inflammation, intestine, macrophages",

author = "Julia Farache and Ehud Zigmond and Guy Shakhar and Steffen Jung",

note = "Leona M and Harry B Helmsley Charitable TrustThis work was supported by the The Leona M and Harry B Helmsley Charitable Trust. SJ is a Helmsley Scholar at the Crohn's & Colitis Foundation.",

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AU - Shakhar, Guy

AU - Jung, Steffen

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AB - Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103 + dendritic cells and CX3CR1 + macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).

KW - dendritic cells

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KW - inflammation

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Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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