Construction of Acyclic Vicinal Tertiary and Quaternary Carbon Stereocenters via a Pd-Catalyzed Allylic Alkylation of Stereodefined Polysubstituted Ketene Aminals

Jianqiang Huang; Ilan Marek

doi:10.1002/ejoc.201901741

Construction of Acyclic Vicinal Tertiary and Quaternary Carbon Stereocenters via a Pd-Catalyzed Allylic Alkylation of Stereodefined Polysubstituted Ketene Aminals

Jianqiang Huang, Ilan Marek

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The Pd/Segphos-catalyzed allylations of stereodefined polysubstituted ketene aminals provide an easy and straightforward access to vicinal acyclic tertiary and quaternary carbon stereocenters with very high diastereo- and enantioselectivity. All possible stereoisomers could be achieved through this diastereodivergent approach.

Original language	English
Pages (from-to)	3133-3137
Number of pages	5
Journal	European Journal of Organic Chemistry
Volume	2020
Issue number	21
DOIs	https://doi.org/10.1002/ejoc.201901741
State	Published - 8 Jun 2020

Keywords

Acyclic systems
Allylation
Quaternary carbon center
Stereodivergency
Tertiary carbon center

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.201901741

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title = "Construction of Acyclic Vicinal Tertiary and Quaternary Carbon Stereocenters via a Pd-Catalyzed Allylic Alkylation of Stereodefined Polysubstituted Ketene Aminals",

abstract = "The Pd/Segphos-catalyzed allylations of stereodefined polysubstituted ketene aminals provide an easy and straightforward access to vicinal acyclic tertiary and quaternary carbon stereocenters with very high diastereo- and enantioselectivity. All possible stereoisomers could be achieved through this diastereodivergent approach.",

keywords = "Acyclic systems, Allylation, Quaternary carbon center, Stereodivergency, Tertiary carbon center",

author = "Jianqiang Huang and Ilan Marek",

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year = "2020",

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doi = "10.1002/ejoc.201901741",

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AU - Marek, Ilan

PY - 2020/6/8

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N2 - The Pd/Segphos-catalyzed allylations of stereodefined polysubstituted ketene aminals provide an easy and straightforward access to vicinal acyclic tertiary and quaternary carbon stereocenters with very high diastereo- and enantioselectivity. All possible stereoisomers could be achieved through this diastereodivergent approach.

AB - The Pd/Segphos-catalyzed allylations of stereodefined polysubstituted ketene aminals provide an easy and straightforward access to vicinal acyclic tertiary and quaternary carbon stereocenters with very high diastereo- and enantioselectivity. All possible stereoisomers could be achieved through this diastereodivergent approach.

KW - Acyclic systems

KW - Allylation

KW - Quaternary carbon center

KW - Stereodivergency

KW - Tertiary carbon center

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DO - 10.1002/ejoc.201901741

M3 - مقالة

SN - 1434-193X

VL - 2020

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EP - 3137

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 21

ER -

Construction of Acyclic Vicinal Tertiary and Quaternary Carbon Stereocenters via a Pd-Catalyzed Allylic Alkylation of Stereodefined Polysubstituted Ketene Aminals

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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