Abstract
AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.
| Original language | English |
|---|---|
| Pages (from-to) | 5305-5309 |
| Number of pages | 5 |
| Journal | World Journal of Gastroenterology |
| Volume | 17 |
| Issue number | 48 |
| DOIs | |
| State | Published - 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Asialoglycoprotein receptor
- Cirrhosis
- Hepatitis c virus
- Liver diagnosis
- Liver function
All Science Journal Classification (ASJC) codes
- Gastroenterology
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