Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

Ron Benyair; Maria Kondratyev; Elena Veselkin; Sandra Tolchinsky; Marina Shenkman; Yoav Lurie; Gerardo Z. Lederkremer

doi:https://doi.org/10.3748/wjg.v17.i48.5305

Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

Ron Benyair, Maria Kondratyev, Elena Veselkin, Sandra Tolchinsky, Marina Shenkman, Yoav Lurie, Gerardo Z. Lederkremer

Department of Cell Research and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.

Original language	English
Pages (from-to)	5305-5309
Number of pages	5
Journal	World Journal of Gastroenterology
Volume	17
Issue number	48
DOIs	https://doi.org/10.3748/wjg.v17.i48.5305
State	Published - 2011

Keywords

Asialoglycoprotein receptor
Cirrhosis
Hepatitis c virus
Liver diagnosis
Liver function

All Science Journal Classification (ASJC) codes

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.3748/wjg.v17.i48.5305

Cite this

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title = "Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis",

abstract = "AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.",

keywords = "Asialoglycoprotein receptor, Cirrhosis, Hepatitis c virus, Liver diagnosis, Liver function",

author = "Ron Benyair and Maria Kondratyev and Elena Veselkin and Sandra Tolchinsky and Marina Shenkman and Yoav Lurie and Lederkremer, {Gerardo Z.}",

year = "2011",

doi = "https://doi.org/10.3748/wjg.v17.i48.5305",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

AU - Benyair, Ron

AU - Kondratyev, Maria

AU - Veselkin, Elena

AU - Tolchinsky, Sandra

AU - Shenkman, Marina

AU - Lurie, Yoav

AU - Lederkremer, Gerardo Z.

PY - 2011

Y1 - 2011

N2 - AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.

AB - AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.RESULTS: The recombinant protein was produced successfully and a specifc ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedCONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.

KW - Asialoglycoprotein receptor

KW - Cirrhosis

KW - Hepatitis c virus

KW - Liver diagnosis

KW - Liver function

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U2 - https://doi.org/10.3748/wjg.v17.i48.5305

DO - https://doi.org/10.3748/wjg.v17.i48.5305

M3 - مقالة

SN - 1007-9327

VL - 17

SP - 5305

EP - 5309

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 48

ER -

Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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